Multi-criteria nuetrosophic method for the diagnosis of phenylketonuria

Abstract

Phenylketonuria (PKU) is a rare genetic disease resulting from mutations in the PAH gene, which interfere with phenylalanine metabolism. The lack of the phenylalanine hydroxylase enzyme leads to an accumulation of phenylalanine in the body, which can cause irreversible damage, including mental retardation and neurological disorders if not treated properly. Early detection is essential to avoid these negative effects, and treatment includes dietary modifications and the use of low-phenylalanine formulas. Timely medical care is key to effective management and improving the quality of life of those affected. The present research aims to implement a multicriteria neutrosophic method for the diagnosis of phenylketonuria. As a result, it was possible to show that phenylketonuria is a rare genetic disease that affects phenylalanine metabolism. Early detection and treatment, which involves dietary changes, are essential to prevent irreversible neurological damage and improve quality of life.